Diastereoselective Synthesis of 1,3,5-Trisubstituted 4-Nitropyrrolidin-2-ones via a Nitro-Mannich/Lactamization Cascade

作者：Pelletier Sophie M C; Ray Peter C; Dixon Darren J^*

来源：Organic Letters, 2011, 13(24): 6406-6409.

DOI：10.1021/ol202710g

A versatile one-pot nitro-Mannich/lactamization cascade for the direct synthesis of 1,3,5-trisubstituted 4-nitropyrrolidin-2-ones has been developed. The reaction is easy to perform and broad in scope, and high levels of diastereoselectivity can be achieved.

• 出版日期2011-12-16