Aminomethylation of lithiated nicotinamide: access to new pyridolactams

作者：Prieur Emilie; Azzouz Rabah; Deguest Geoffrey; Fruit Corinne^*; Bischoff Laurent; Marsais Francis

来源：Tetrahedron Letters, 2008, 49(3): 437-440.

DOI：10.1016/j.tetlet.2007.11.109

• pyridine
• metalation.
• formimine
• lactam
• aminomethylation

New 2,3-dihydropyrrolopyridinones were conveniently prepared by trapping lithiated pyridine carboxamides, with highly reactive formimines. In this Letter, we report that a wide range of N-functionalised compounds can be synthesised in one step by this process, allowing the presence of ethers, acetals or ester moieties.

• 出版日期2008-1-14