Asymmetric Synthesis of (+)-Mequitazine from Quinine

作者：Leroux Sebastien; Larquetoux Laurent; Nicolas Marc; Doris Eric^*

来源：Organic Letters, 2011, 13(13): 3549-3551.

DOI：10.1021/ol2012567

The first asymmetric synthesis of the antihistaminic drug mequitazine is reported. Our approach started from quinine, a Cinchona alkaloid, whose chiral information was exploited for setting up the stereogenic center of (+)-mequitazine.

• 出版日期2011-7-1
• 单位中国地震局