Neuropsychiatric dysfunction in patients with chronic hepatitis and liver cirrhosis

作者：Michitaka Kojiro; Tokumoto Yoshio; Uesugi Kazuhiro; Kisaka Yoshiyasu; Hirooka Masashi; Konishi Ichiro; Mashiba Toshie; Abe Masanori; Hiasa Yoichi; Matsuura Bunzo; Horiike Norio; Shoda Takaaki; Onji Morikazu^*

来源：Hepatology Research, 2008, 38(11): 1069-1075.

DOI：10.1111/j.1872-034X.2008.00374.x

• chronic hepatitis
• hepatic encephalopathy
• liver cirrhosis
• neuropsychiatric test

Aim: The aim of this study is to clarify the cerebral functions in patients with chronic hepatitis (CH) as well as those with liver cirrhosis (LC).
Methods: We studied 58 patients with CH (20 in fibrosis stage F1, 20 in F2, 18 in F3), 77 with LC (46 rated as Child-Pugh class A, 24 as B, 7 as C), and 20 healthy volunteers (HV). Computer-aided quantitative neuropsychiatric function test systems, including eight neuropsychiatric tests were performed.
Results: Subjects with results over the cut-off value for healthy subjects ranged from 11.1-28.6% in CH and 19.5-36.4% in LC. The percentages with abnormality in at least one test in CH and LC were 72.4% and 80.6%, respectively, which were significantly higher than that in the HV group (35.0%) (P = 0.003, P = 0.0003, respectively). Among CH subjects, those with three or more abnormal results in the F1, F2 and F3 subgroups were 15.0%, 20.0% and 38.9%, respectively. Among LC subjects, those with three or more abnormal results in the Child-Pugh class A, B and C subgroups comprised 30.4%, 50.0% and 57.1%, respectively. The rate in the CH F3 subgroup (P = 0.011) and in all three LC subgroups (P = 0.023, P = 0.001, P = 0.002, respectively) were significantly higher than that in the HV group.
Conclusion: The percentage of patients with neuropsychiatric function impairment was high in both LC and CH, especially in stage F3. Neuropsychiatric dysfunction may initiate in CH in a considerable number of patients.

• 出版日期2008-11