Acquisition of Mycobacterium abscessus among ventilator-dependent patients in Taiwan chronic respiratory care facilities

作者：Lee Meng Rui; Tsai Chia Jung; Hu Jia Ying; Lee Shih Wei; Ko Jen Chung; Wang Hao Chien; Yu Chong Jen; Lee Li Na; Hsueh Po Ren^*

来源：Future Microbiology, 2016, 11(4): 491-500.

DOI：10.2217/fmb.16.6

• chronic respiratory care wards
• dendrogram
• M. abscessus
• M. abscessus subspeciesabscessus
• M. abscessus subspecies massiliense
• nontuberculous mycobacteria
• Taiwan
• ventilator-dependent patients

Aim: To investigate the acquisition of Mycobacterium abscessus among ventilator-dependent patients. Materials & methods: We prospectively recruited ventilator-dependent patients in five respiratory care wards (RCWs). Respiratory specimens were cultured for mycobacteria on day 1 (D1), 3 months (M3) and 6 months (M6) after enrollment. Results: 72 patients had cultures taken at all three time points. The proportion of patients with a culture positive for M. abscessus increased from 15.3% (11/72) on D1 to 30.6% (22/72) at M3 and 38.9% (28/72) at M6. Two M. abscessus subspecies abscessus isolates obtained from different patients had identical randomly amplified polymorphic DNA patterns. Being in RCW D and advanced age were significantly associated with initial cultures positivity. Conclusion: Our study reveals that acquisition of M. abscessus was common among ventilator-dependent patients.

• 出版日期2016