Regioselective N-Methylation of 6-Chloroindolo[3,2-c]quinolines and Their Amination Reactivity at the C-6 Position

作者：Wang Ning; Imai Kento; Pang Cui Qing; Wang Ming qi; Yonezawa Mizuho; Zhang Yu; Nokami Junzo; Inokuchi Tsutomu^*

来源：Bulletin of the Chemical Society of Japan, 2013, 86(7): 864-869.

DOI：10.1246/bcsj.20130063

The treatment of 6-chloroindolo[3,2-c]quinoline 6 with NaH-MeI led to methylation at N-11, forming 8, while the reaction of 6 with MeI with heating gave the corresponding 5-methylated quinolinium salt whose SNAr with water smoothly proceeded to form 5-methylindolo[3,2-c]quinolin-6-one 3b. The amination reactivity at the C-6 was assigned in the order of 6 %26gt; 11-methylated 8.

• 出版日期2013-7-15