A new Mucocutaneous Activity Index for Behcet's disease

作者：Mumcu G^*; Inanc N; Taze A; Ergun T; Direskeneli H

来源：Clinical and Experimental Rheumatology, 2014, 32(4): S80-S86.

• Behcet's disease
• activity
• index
• mucocutaneous
• treatment
• symptoms

Objective. Patient-reported outcomes are increasingly accepted to be major domains in chronic disorders. The aim of this study was to develop a patient-derived disease activity index in Behcet's disease (BD).
Methods. One hundred and seventy-seven BD patients (M/F: 69/108) were included in the study. Data were collected by clinical examination and a questionnaire regarding a Mucocutaneous Index (MI) with genital ulcer activity (GI), erythema nodosum activity (El) and the composite index (Cl) for oral ulcers, as subscales of it. Self-reported treatment evaluation was carried out as criterion validity. Patients whose symptoms completely disappeared or decreased significantly, were categorised as "improved group", others were classified as "non-improved group".
Results. Among the study group, 79.7% of the patients (n=141) were active, whereas 20.3% were inactive (n=36). Scores of Cl, GI, El and MI score were 0+/-0 in inactive ones, whereas scores were 5.65+/-2.36 for CI, 0.81+/-2.34 for GI, 0.91+/-2.35 for El and 6.25+/-5.1 for MI in actives (p=0.000 for all). MI score was significantly higher in non-improved group" (65.5%) compared to "improved group" (34.5%) (p<0.0001).
Conclusion. The mucocutaneous activity index may help decision-making process for treatment strategies in BD patients.

• 出版日期2014-8