PAFc, a Key Player in MLL-rearranged Leukemogenesis

作者：Tan Jiaying; Muntean Andrew G; Hess Jay L^*

来源：Oncotarget, 2010, 1(6): 461-465.

• oncoprotein
• leukemia
• oncotarget
• transcription

Recent studies identified an interaction between the Polymerase Associated Factor complex (PAFc) and Mixed Lineage Leukemia (MLL), including MLL-rearranged oncoproteins. This interaction is critical for MLL transcriptional activity and MLL-rearranged leukemogenesis. Here, we discuss the potential molecular role of the PAFc in transcriptional dysregulation of MLL target genes and the interplay between PAFc and MLL-rearranged oncoproteins in leukemogenesis.

• 出版日期2010-10