Nickel or Phenanthroline Mediated Intramolecular Arylation of sp(3) C-H Bonds Using Aryl Halides

作者：Wertjes William C; Wolfe Lydia C; Waller Peter J; Kalyani Dipannita^*

来源：Organic Letters, 2013, 15(23): 5986-5989.

DOI：10.1021/ol402869h

The development of the intramolecular arylation of sp(3) C-H bonds adjacent to nitrogen using aryl halides is described. Arylation was accomplished using either Ni(COD)(2) or 1,10-phenanthroline in substoichiometric amounts, and the reaction conditions were applied to a variety of electronically differentiated benzamide substrates. Preliminary studies suggest a mechanism involving aryl and alkyl radical intermediates.

• 出版日期2013-12-6