Moisturizing effect of serine-loaded solid lipid nanoparticles and polysaccharide-rich extract of root Phragmites communis incorporated in hydrogel bases

作者：Barua Sonia; Kim Hyeongmin; Hong Seong Chul; Yoo Seung Yup; Shin Dohyun; Lee Chung Lyol; Na Seon Jeong; Kim Yeong Hyo; Jo Kanghee; Yun Gyiae; Kim Joong Hark; Sohn Uy Dong; Lee Jaehwi^*

来源：Archives of Pharmacal Research, 2017, 40(2): 250-257.

DOI：10.1007/s12272-016-0846-1

• Phragmites rhizoma
• Reed root extract
• Serine
• Solid lipid nanoparticles
• Skin moisturization

This study evaluated the moisturizing effect of serine-loaded solid lipid nanoparticles (serine-SLN) and polysaccharide-rich reed (Phragmites communis) root extract (RRE) incorporated in hydrogel bases. The hydrogels with serine-SLN and/or RRE were carefully applied on the volar forearm of human volunteers. Their moisturizing efficacy was evaluated by monitoring conductance values using a skin surface hygrometer. The values of the area under the normalized conductance-time curve (AUCC) were developed and compared as a parameter for the water holding capacity of the skin. Hydrogels with serine-SLN did not significantly moisturize the skin, while hydrogel containing 0.25% RRE produced a significant increase in the moisture content of the skin. However, adding more than 0.25% of RRE into the hydrogel base decreased the moisturizing effect due to the marked reduction of viscosity. Significantly enhanced moisturizing effect was observed with the hydrogel containing 0.25% RRE and 3% serine-SLN, with AUCC increased 2.21 times compared to than blank hydrogel. The results imply that effective delivery of serine into the skin is possible using lipid-based nanocarriers and RRE, which could be a promising strategy to moisturize the skin effectively.

• 出版日期2017-2