A biocompatible calcium bisphosphonate coordination polymer: towards a metal-linker synergistic therapeutic effect?

作者:Alvarez Elsa*; Marquez Alfonso Garcia; Devic Thomas; Steunou Nathalie; Serre Christian; Bonhomme Christian; Gervais Christel; Izquierdo Barba Isabel; Vallet Regi Maria; Laurencin Danielle; Mauri Francesco; Horcajada Patricia
来源:CrystEngComm, 2013, 15(46): 9899-9905.
DOI:10.1039/c3ce41346b

摘要

A novel, biocompatible, calcium-based coordination polymer was hydrothermally synthesized using as linker the bone antiresorptive bisphosphonate alendronate. Its structure was determined using single-crystal X-ray diffraction and characterized by chemical analysis, infrared spectroscopy (IR), X-ray powder diffraction (XRPD), solid state nuclear magnetic resonance (NMR) and thermogravimetric analysis (TGA). Its bioactivity was finally evaluated in vitro, revealing a very high stability towards simulated body fluid.

  • 出版日期2013