Alcoholic Myopathy: Pathophysiologic Mechanisms and Clinical implications

作者：Simon Liz; Jolley Sarah E; Molina Patricia E

来源：Alcohol Research & Health, 2017, 38(2): 207-217.

• Alcohol consumption
• alcohol use disorder
• alcohol effects and consequences
• alcoholic myopathy
• skeletal muscle
• skeletal muscle dysfunction
• myopathy
• muscle

Skeletal muscle dysi.e., myopathy) is common in patients with alcohol use disorder. However, few clinical studies have elucidated the significance, mechanisms, and Therapeutic options of alcohol-related myopathy. Preclinical studies indicate that alcohol adversely affects both anabolic and catabolic pathways of muscle-mass maintenance and that an increased proinflammatory and oxidative milieu in the skeletal muscle is the primary contributing factor leading to alcohol-related skeletal muscle dysfunction. Decreased regenerative capacity of muscle progenitor cells is emerging as an additional mechanism that contributes to alcohol-induced loss in muscle mass and impairment in muscle growth. This review details the epidemiology of alcoholic myopathy, potential contributing pathophysiologic mechanisms, and emerging literature on novel therapeutic options.

• 出版日期2017