A polymorphism in a staphylococcal enterotoxin receptor gene (T cell receptor BV3 recombination signal sequence) is not associated with unexplained sudden unexpected death in infancy in an Australian cohort

作者：Highet Amanda R^*; Gibson Catherine S; Goldwater Paul N

来源：Microbial Pathogenesis, 2010, 49(1-2): 51-53.

DOI：10.1016/j.micpath.2010.03.012

• Staphylococcus aureus
• Genetic polymorphism
• Sudden infant death
• Enterotoxins
• T cell receptors

Polymorphisms in genes that influence the expression of toxin receptors could contribute to Sudden Infant Death Syndrome (SIDS) and unexplained Sudden Unexpected Death in Infancy (uSUDI) for which there is evidence of toxin involvement. We aimed to determine whether TCRBV3S1 allele 2 could be involved in a staphylococcal toxic shock hypothesis for uSUDI. Observed frequencies of the TCRBV3S1*2 allele and genotype in 48 Australian uSUDI cases and 96 live comparison infants did not differ In future the role of other toxin receptor gene polymorphisms deserves investigation.

• 出版日期2010-8