科研之友
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摘要
Background: Organometallic alkyne complexes of the hexacarbonyl dicobalt type (hexacarbonyl[mu-eta(4)-(alkyne)]dicobalt (Co - Co) complexes) are an interesting class of compounds used in modern synthetic chemistry and an increasing number of reports deal also with the use of these complexes in the field of medicinal chemistry. Methods: This review highlights the applications of alkyne hexacarbonyl dicobalt species in biomedical research with a focus on anticancer drug development. Medline, Pubmed, Scifinder and Espacenet internet databases were searched for available literature and patents. Results/conclusion: Preclinical studies on hexacarbonyl dicobalt complexes containing various alkyne (bio)ligands demonstrated a high potential for application (e.g., as antitumor drugs, hormonally active or diagnostic agents). The biological properties of the compounds were mainly determined by the nature of the ligands and the presence of the metal center.
- 出版日期2008-3
