An approach to alicyclic ring-fused xanthines

作者：Liubchak Kostiantyn^*; Tolmachev Andrey; Grygorenko Oleksandr O; Nazarenko Kostiantyn

来源：Tetrahedron, 2012, 68(41): 8564-8571.

DOI：10.1016/j.tet.2012.08.014

• Nitrogen heterocycles
• Copper-catalyzed arylation
• Imidazoles
• Xantines
• Amidines

A convenient three-step approach to the synthesis of five to eight-membered alicyclic ring-fused xanthines was developed. The method included reaction of lactim or thiolactim ethers with 6-aminouracils, followed by bromination and copper-catalyzed arylation. The procedure allowed preparation of the title compounds in 21-36% overall yields.

• 出版日期2012-10-14