Multimetallic Ir-Sn-3-catalyzed substitution reaction of pi-activated alcohols with carbon and heteroatom nucleophiles

作者：Maity Arnab Kumar; Chatterjee Paresh Nath; Roy Sujit^*

来源：Tetrahedron, 2013, 69(2): 942-956.

DOI：10.1016/j.tet.2012.10.086

An atom economic and catalytic substitution reaction of pi-activated alcohols by a multimetallic Ir-Sn-3 complex has been demonstrated. The multimetallic Ir-Sn-3 complex can be easily synthesized from the reaction between [Cp*IrCl2](2) and SnCl2. In presence of as little as 1 mol% of the catalyst three different types of pi-activated alcohols, namely benzyl, allyl, and propargyl alcohols, have been successfully transformed into alkylated products using carbon (arenes, heteroarenes, allyltrimethylsilane, and 1,3-dicarbonyls), nitrogen (sulfonamides), oxygen (alcohols), and sulfur (thiols) nucleophiles in very high yields. An electrophilic mechanism is proposed from the Hammett correlation study.

• 出版日期2013-1-14