Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment

作者：Garcia Echeverria Carlos^*

来源：Bioorganic & Medicinal Chemistry Letters, 2010, 20(15): 4308-4312.

DOI：10.1016/j.bmcl.2010.05.099

• Kinase inhibitors
• mTOR
• Anticancer agents

Over the past few years a number of components of the PI3K/mTOR pathway have been the subject of intense drug discovery activities both in pharmaceutical companies and in academia. This review article summarizes progress made in the identification and development of allosteric and ATP-competitive kinase inhibitors of mTOR and their potential therapeutic use in oncology.

• 出版日期2010-8-1