Association between interleukin-10 gene-592 C/A polymorphism and the risk of type 2 diabetes mellitus: A meta-analysis of 5320 subjects

作者：Yin, Yan-Wei^*; Sun, Qian-Qian; Zhang, Bei-Bei; Hu, Ai-Min; Liu, Hong-Li; Wang, Qi; Zeng, Yi-Hua; Xu, Rui-Jia; Ma, Jian-Bin; Shi, Long-Bao

来源：Human Immunology, 2012, 73(9): 960-965.

DOI：10.1016/j.humimm.2012.06.006

• PREVALENCE
• OBESITY

Increasing evidence suggests that interleukin-10 (IL-10) gene -592 C/A polymorphism may be associated with an increased risk of type 2 diabetes mellitus (T2DM). To provide a quantitative assessment of the association between this variant and risk of T2DM, we performed this meta-analysis. Systematic searches of electronic databases PubMed, Embase, Web of Science, CBMdisc and CNKI, as well as hand searching of the references of identified articles were performed. A total of 2698 T2DM cases and 2622 controls in seven case-control studies were included in this meta-analysis. The results showed no evidence for significant association between IL-10 gene -592 C/A polymorphism and T2DM risk (for A allele vs. C allele: OR = 0.94, 95% CI = 0.69-1.29, p = 0.69; for A/A vs. C/C: OR = 0.88, 95% CI = 0.39-1.98, p = 0.75; for A/A vs. A/C + C/C: OR= 1.04, 95% CI = 0.59-1.82, p = 0.89; for A/A + A/C vs. C/C: OR = 1.11, 95% CI = 0.73-1.69, p = 0.61). In addition, the similar results were obtained in the subgroup analysis based on the ethnicity. In summary, results from this meta-analysis suggest that the IL-10 gene -592 C/A polymorphism is not associated with T2DM risk.

• 出版日期2012-9
• 单位中国人民解放军成都军区总医院; 中国人民解放军空军总医院