A Versatile Approach to 2-Substituted 3-Trifluoromethyl-1,3-diols Based on the Reaction of Trifluoroacetaldehyde Ethyl Hemiacetal with Enamines Derived from Aldehydes

作者:Funabiki Kazumasa*; Furuno Yudai; Sato Fumiaki; Gonda Hiroshi; Kubota Yasuhiro; Matsui Masaki
来源:Chemistry Letters, 2010, 39(4): 410-411.
DOI:10.1246/cl.2010.410

摘要

Treatment of trifluoroacetaldehyde ethyl hemiacetal with various enamines, derived from various aldehydes, at room temperature, followed by hydrolysis with 10% HCl aqueous solution and reduction with sodium borohydride in ethanol, gave 2-substituted 3-trifluoromethyl-1,3-diols in good yields with fair to good diastereoselectivities.

  • 出版日期2010-4-5