A BRANCHING PROCESS FOR VIRUS SURVIVAL

作者:Cox J Theodore*; Schinazi Rinaldo B
来源:Journal of Applied Probability, 2012, 49(3): 888-894.
DOI:10.1239/jap/1346955342

摘要

Quasispecies theory predicts that there is a critical mutation probability above which a viral population will go extinct. Above this threshold the virus loses the ability to replicate the best-adapted genotype, leading to a population composed of low replicating mutants that is eventually doomed. We propose a new branching model that shows that this is not necessarily so. That is, a population composed of ever changing mutants may survive.

  • 出版日期2012-9