Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV

作者：Maruyama Tokumi^*; Demizu Yosuke; Kozai Shigetada; Witvrouw Myriarn; Pannecouque Christophe; Balzarini Jan; Snoecks Robert; Andrei Graciella; De Clercq Erik

来源：Nucleosides Nucleotides & Nucleic Acids, 2007, 26(10-12): 1553-1558.

DOI：10.1080/15257770701545424

• uracil derivatives
• human immunodeficiency virus
• human cytomegalovirus
• antiviral activity

Antiviral activity of 1,3-disubstituted uracil derivatives was evaluated against HIV-1 and HCMV It appears that the nitrogen of the 1-cyanomethyl group is important for anti-HIV-1 activity, suggesting interaction with the amino acid residues of HIV-1 reverse transcriptase. 1-Arylmethyl derivatives also exhibited good anti-HIV-1 activity; and that of the 2- and 4-picolyl derivatives was particularly excellent.

• 出版日期2007
• 单位河北医科大学