An Efficient One-Pot Organocatalyzed Synthesis of Spiro[Chroman-3,6 '-Furo[2,3-d]Pyrimidine]-Tetraones

作者：Ahadi Somayeh; Mirzaei Peiman; Bazgir Ayoob^*

来源：Combinatorial Chemistry & High Throughput Screening, 2013, 16(6): 435-440.

• Barbituric acid
• coumarine
• spirochroman-furopyrimidine

An efficient synthesis of new spiro[chroman-3,6'-furo[2,3-d]pyrimidine]- tetraones by an organocatalyzed three-component condensation reaction of aldehydes, barbituric acids and 3-bromo-4-hydroxy-2H-chromen-2-one in refluxing acetic acid in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) is reported. We are hopeful that the products will lead to a wider range pharmacological and physiological activity.

• 出版日期2013-7