Adolescents with moyamoya disease: clinical features, surgical treatment and long-term outcomes

作者：Zhao, Meng; Zhang, Dong; Wang, Shuo; Zhang, Yan; Wang, Rong; Deng, Xiaofeng; Gao, Faliang; Zhao, Jizong^*

来源：Acta Neurochirurgica, 2017, 159(11): 2071-2080.

DOI：10.1007/s00701-017-3286-x

• Moyamoya disease
• Adolescent
• Revascularization
• Stroke
• Outcome

This study aimed to elucidate the clinical features, surgical treatment and long-term outcomes of adolescent patients with moyamoya disease. @@@ We reviewed consecutive patients with moyamoya vasculopathy who were admitted to our hospital from 2009 to 2015 to identify adolescent patients with moyamoya disease. Clinical features, surgical treatment and long-term outcomes were analyzed. Follow-up was performed by face-to-face or structured telephone interviews. Outcome measures were future stroke events. We performed univariate and multivariate time-to-event analyses to identify risk factors associated with future stroke events. @@@ A total of 95 adolescent patients with moyamoya disease (age at onset, 13.1 +/- 2.3 years) were included in this study. During follow-up, 12 patients (12.6%) had stroke events. We found that the patients who underwent direct/combined bypass had a significantly lower risk of future strokes [hazard ratio (HR), 0.16; 95% confidence interval (CI), 0.03-0.74; P = 0.019] compared to patients who underwent indirect bypass. @@@ Our results demonstrate that direct/combined bypass can be more effective in preventing future strokes than indirect bypass in adolescent patients with moyamoya disease.

• 出版日期2017-11
• 单位首都医科大学