Acute akathisia with quetiapine: A case report and review of literature

作者:Shah Ruchita; Grover Sandeep*; Maheshwari Uma; Kate Natasha; Malhotra Nidhi
来源:Indian Journal of Pharmacology, 2010, 42(6): 416-417.
DOI:10.4103/0253-7613.71896

摘要

Quetiapine is an atypical antipsychotic which has been shown to have greater relative affinity for 5-HT(2A) receptors than for D(2) receptors, due to which it is thought to lead to lower incidence of extrapyramidal symptoms (EPS). However, over the years literature in the form of case reports have accumulated which shows that quetiapine can lead to akathisia, especially in subjects prone to develop EPS. In this study, we report the case of a 22-year-old female who developed akathisia with quetiapine 150 mg/day, which subsided with reduction in dose. We have also reviewed the existing literature with respect to akathisia with quetiapine.