Docetaxel, cisplatin and 5-fluorouracil-based induction chemotherapy followed by intensity-modulated radiotherapy concurrent with cisplatin in locally advanced EBV-related nasopharyngeal cancer

作者：Bossi P; Orlandi E; Bergamini C; Locati L D; Granata R; Mirabile A; Parolini D; Franceschini M; Fallai C; Olmi P; Quattrone P; Potepan P; Gloghini A; Miceli R; Mattana F; Scaramellini G; Licitra L^*

来源：Annals of Oncology, 2011, 22(11): 2495-2500.

DOI：10.1093/annonc/mdq783

• cisplatin
• docetaxel
• induction chemotherapy
• intensity-modulated radiotherapy
• nasopharyngeal carcinoma

Background: This monocentric study evaluates the activity and tolerability of docetaxel (Taxotere), cisplatin and 5-luorouracil (5-FU) (TPF) induction chemotherapy followed by intensity-modulated radiotherapy (IMRT) concurrent with high-dose cisplatin in Epstein-Barr virus -related locally advanced undifferentiated nasopharyngeal cancer.
Patients and methods: We retrospectively reviewed the records of patients who received induction docetaxel 75 mg/m(2) and cisplatin 75 mg/m(2) on day 1, and 5-FU 750 mg/m(2)/day (96-h continuous infusion). Following induction, patients received full doses of IMRT concurrently with cisplatin 100 mg/m(2) every 21 days for three cycles.
Results: Thirty patients received three TPF cycles (median). Induction was well tolerated; the main toxicity was neutropenia (33%, grade 3-4). During chemoradiotherapy, neutropenia (40%) and mucositis (43%) were the most frequent grade 3-4 adverse events. Mean dose of IMRT was 68.8 Gy. Worst late toxicity was xerostomia. Complete response rate was 93%. At 35 months, two patients had locoregional recurrence, three had distant metastases, and one had both. Three-year progression-free survival and overall survival were 79% [95% confidence interval (CI) 64% to 94%] and 87% (95% CI 74%- to 100%), respectively.
Conclusions: In this high-stage nonendemic cancer population, TPF followed by high-dose cisplatin IMRT was promising; this treatment approach deserves evaluation in randomized trials.

• 出版日期2011-11