ALPHA-CRYSTALLINE ANTIBODIES IN NON-SMALL CELL LUNG CANCER PATIENTS

作者:Cherneva Radostina*; Georgiev Ognian; Petrov Danail; Slavova Yanina; Toncheva Draga; Bechev Blagovest; Stamenova Maria; Trifonova Nedka
来源:Comptes Rendus de l Academie Bulgare des Sciences, 2009, 62(12): 1615-1620.

摘要

The investigation of biomarkers in peripheral blood of cancer patients makes it useful for clinical application. The aim of the study was to explore and compare the levels of alpha-crystalline antibodies in non-small cell lung cancer patients (NSCLC), high risk chronic obstructive pulmonary disease (COPD) patients and healthy volunteers. Alpha-crystalline antibodies were detected with ELISA in 51 NSCLC patients, 38 high risk COPD patients and 52 age and sex matched healthy volunteers. Alpha-crystalline IgG antibodies differed significantly between the groups of cancer patients and the healthy volunteers (p < 0.0001). The assay was effective in distinguishing the patients with and without lymphogenic metastatic spread of the disease (p = 0.054).
The clinical significance of alpha-crystalline antibodies has a modest implication for screening in high risk groups. Its importance as a marker for molecular staging and lymph node micrometastasis should be further explored.

  • 出版日期2009