Autophagy in neurodegeneration: two sides of the same coin

作者：Lee Jin A^*

来源：BMB Reports, 2009, 42(6): 324-330.

DOI：10.5483/bmbrep.2009.42.6.324

• Autophagy
• Cell death
• Cell survival
• Neurodegeneration

Autophagy is a bulk lysosomal degradation process important in development differentiation and cellular homeostasis in multiple organs. Interestingly, neuronal survival is highly dependent on autophagy due to its post-mitotic nature, polarized morphology and active protein trafficking. A growing body of evidence now suggests that alteration or dysfunction of autophagy causes accumulation of abnormal proteins and/or damaged organelles, thereby leading to neurodegenerative disease. Although autophagy generally prevents neuronal cell death, it plays a protective or detrimental role in neurodegenerative disease depending on the environment In this review, the two sides of autophagy will be discussed in the context of several neurodegenerative diseases. [BMB reports 2009; 42(6): 324-330]

• 出版日期2009-6-30