MT2-MMP Expression During Early Avian Morphogenesis

作者：Patterson Rachel A; Cavanaugh Ann M; Cantemir Veronica; Brauer Philip R; Reedy Mark V^*

来源：Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology, 2013, 296(1): 64-70.

DOI：10.1002/ar.22618

• MT2-MMP
• MMP15
• chicken embryo
• MMP

Membrane-type 2 matrix metalloproteinase (MT2-MMP; also called MMP15) is a membrane-bound protease that degrades extracellular matrix and activates proMMPs such as proMMP-2. MMP-2 expression in avian embryos is well documented, but it is not clear how proMMP-2 is activated during avian embryogenesis. Herein, we report that MT2-MMP mRNA is expressed in several tissues including the neural folds and epidermal ecto-derm, intermediate mesoderm, pharyngeal arches, limb buds, and dermis. Several, but not all, of these tissues are known to express MMP-2. These observations suggest MT2-MMP may play a role during embryonic development not only through its own proteolytic activity but also by activating proMMP-2. Anat Rec, 296: 64-70, 2013.

• 出版日期2013-1