Application of pd(0)-catalyzed intramolecular oxazine formation to the efficient total synthesis of (-)-anisomycin

作者：Joo Jae Eun; Lee Kee Young; Pham Van Thoai; Tian Yong Shou; Ham Won Hun^*

来源：Organic Letters, 2007, 9(18): 3627-3630.

DOI：10.1021/ol701519b

The enantioselective total synthesis of (-)-anisomycin, a potent antibiotic agent, has been achieved. The key steps are a Pd(0)-catalyzed stereoselective intramolecular oxazine formation from D-tyrosine and pyrrolidine formation by catalytic hydrogenation of the oxazine.

• 出版日期2007-8-30