A Novel Tripeptide Derived from Chlorella vulgaris Regulates Skin Homeostasis Through Antioxidant Activity

作者：Han Jae Gap; Kulkarni Atul; Jeon Jin Young; Kim Bo Ra; Song Mi Young; Jeong Hee Yong; Yang Dong Joo; You Seung Hun; Kim Ki Woo; Moh Sang Hyun^*; Hwang Jae Kwan

来源：Science of Advanced Materials, 2015, 7(11): 2476-2480.

DOI：10.1166/sam.2015.2434

• Chlorella vulgaris
• CAS Tripeptide
• Antioxidant
• Anti-Aging

The marine green alga Chlorella vulgaris produces secondary metabolites including functional nutrients and associated bioactive peptides for protection against harmful environmental stress, suggesting that C. vulgaris extracts may be beneficial for skin homeostasis via protection against UV radiation and reactive oxygen species (ROS). In this study, we identified a cysteine-alanine-serine (CAS) tripeptide from C. vulgaris using LC-MS/MS and NMR and investigated whether the CAS tripeptide can protect skin cells from ROS species. CAS tripeptide was added to a human skin cell line and this treatment resulted in the upregulation of antioxidant genes. In addition, we identified significant induction of procollagen C endopeptidase enhancer (PCOLCE) protein production, which is related to skin firming, due to exposure to CAS tripeptide. The combined results suggest that the microalgae-derived CAS tripeptide might be a valuable biomaterial for modulation of skin homeostasis through antioxidant activity.

• 出版日期2015-11