Adaptive molecular networks controlling chemotactic migration: dynamic inputs and selection of the network architecture

作者：Chang Hao; Levchenko Andre^*

来源：Philosophical Transactions of the Royal Society B-Biological Sciences, 2013, 368(1629): 20130117.

DOI：10.1098/rstb.2013.0117

• perfect adaptation
• model
• chemotaxis

Eukaryotic signalling networks underlying the cell's ability to sense the gradient of chemotactic cues frequently have the dual property of perfect adaptation to spatially homogeneous inputs, and persistent activation by inputs that are spatially graded. This property is also shared by bacterial chemotaxis networks, raising the question of whether these two types of chemotactic processes also have similar organization of the underlying bio-molecular processes. Interestingly, perfect adaptation can only be achieved robustly by a handful of mechanisms, and while eukaryotic chemotactic networks appear to rely on one of these-the incoherent feed-forward loop, bacterial chemotaxis depends on another-the negative feedback loop. In this review, we discuss how this conclusion can be reached even if the details of the molecular networks are incompletely understood. Furthermore, we argue that the use of distinct network architectures is not accidental and may be a consequence of the nature of the signalling inputs and the limitations of the sensory properties of different cell types.

• 出版日期2013-11-5