Analysis of Ischemia/Reperfusion Injury in Time-Zero Biopsies Predicts Liver Allograft Outcomes

作者：Ali Jason M; Davies Susan E; Brais Rebecca J; Randle Lucy V; Klinck John R; Allison Michael E D; Chen Yining; Pasea Laura; Harper Simon F J; Pettigrew Gavin J^*

来源：Liver Transplantation, 2015, 21(4): 487-499.

DOI：10.1002/lt.24072

Ischemia/reperfusion injury (IRI) that develops after liver implantation may prejudice long-term graft survival, but it remains poorly understood. Here we correlate the severity of IRIs that were determined by histological grading of time-zero biopsies sampled after graft revascularization with patient and graft outcomes. Time-zero biopsies of 476 liver transplants performed at our center between 2000 and 2010 were graded as follows: nil (10.5%), mild (58.8%), moderate (26.1%), and severe (4.6%). Severe IRI was associated with donor age, donation after circulatory death, prolonged cold ischemia time, and liver steatosis, but it was also associated with increased rates of primary non9.1%) and retransplantation within 90 days (22.7%). Longer term outcomes in the severe IRI group were also poor, with 1-year graft and patient survival rates of only 55% and 68%, respectively (cf. 90% and 93% for the remainder). Severe IRI on the time-zero biopsy was, in a multivariate analysis, an independent determinant of 1-year graft survival and was a better predictor of 1-year graft loss than liver steatosis, early graft dysfunction syndrome, and high first-week alanine aminotransferase with a positive predictive value of 45%. Time-zero biopsies predict adverse clinical outcomes after liver transplantation, and severe IRI upon biopsy signals the likely need for early retransplantation. Liver Transpl 21:487-499, 2015.

• 出版日期2015-4