Asymmetric Synthesis of Unnatural Amino Acids and Tamsulosin Chiral Intermediate

作者：Arava Veera Reddy^*; Amasa Srinivasulu Reddy; Bhatthula Bharat Kumar Goud; Kompella Laxmi Srinivas; Matta Venkata Prasad; Subha M C S

来源：Synthetic Communications, 2013, 43(21): 2892-2897.

DOI：10.1080/00397911.2012.748075

• Asymmetric hydrogenation
• chiral metal catalyst
• [(S)-BINAPRuCl (benzene)]Cl
• tamsulosin intermediate
• unnatural amino acids

An efficient and enantioselective hydrogenation of N-acetylamino phenyl acrylic acids was successfully developed by using ruthenium catalyst. This methodology is important in the field of pharmaceuticals and provides a new process for the preparation of unnatural amino acids and tamsulosin chiral intermediate. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource: Full experimental and spectral details.]

• 出版日期2013-11-2