Hemifacial spasm and reinnervation synkinesias: long-term treatment with either Botox(A (R)) or Dysport(A (R))

作者：Kollewe Katja^*; Mohammadi Bahram; Dengler Reinhard; Dressler Dirk

来源：Journal of Neural Transmission, 2010, 117(6): 759-763.

DOI：10.1007/s00702-010-0409-4

• Hemifacial spasm
• Reinnervation sykinesias
• Botulinum toxin
• Conversion factor
• Botox (R)
• Dysport (R)

Botulinum toxin is considered the treatment of choice for hemifacial spasm (HFS) and reinnervation synkinesias (RS). We present 133 patients with HFS (n = 97) and RS (n = 36) who have been treated with either Botox(A (R)) (n = 78) or Dysport(A (R)) (n = 55) exclusively for 6 years (range 2-12 years). The Botox(A (R)) dose was 21 +/- A 8 MU, the Dysport(A (R)) dose 46 +/- A 22 MU. The therapeutic effect started after 7.1 +/- A 2.3 days and lasted for 12.5 +/- A 3.9 weeks. It was stable throughout the observation period in 85% of all patients. Adverse effects occurred in 5.4% of injection series. No patient terminated treatment because of unsatisfactory results. Secondary therapy failure did not occur. With an effective conversion ratio of Botox(A (R)):Dysport(A (R)) = 1:2.56 there were no differences between both drugs with respect to therapeutic efficacy and adverse effects thus confirming the hypothesis that there may not be intrinsic differences between both products.

• 出版日期2010-6