A novel translocation t(11;13) (q21;q14.2) in a child with suprasellar primitive neuroectodermal tumor and retinoblastoma

作者:Huddleston Stephen; McNall Knapp Rene Y; Siatkowski Michael; Odom Christine; Brennan Rachel; Wilson Matthew W*
来源:Ophthalmic Genetics, 2013, 34(1-2): 97-100.
DOI:10.3109/13816810.2012.719058

摘要

Purpose: To report on a novel translocation related to a suprasellar primitive neuroectodermal tumor (sPNET) and retinoblastoma. %26lt;br%26gt;Design: Case report. %26lt;br%26gt;Methods: A 6-year-old girl underwent genetic testing after developing unilateral retinoblastoma subsequent to treatment (surgery, chemotherapy, and stem-cell rescue) for a sPNET found at 1 year of age. %26lt;br%26gt;Results: Genetic testing found the girl%26apos;s karyotype to be 46, XX, t(11;13)(q21;q14.2); a novel translocation not previously reported in patients with either retinoblastoma or sPNET. %26lt;br%26gt;Conclusions: Our patient had a novel translocation affecting the retinoblastoma 1 (RB1) gene, 46,XX,t(11;13) (q21;q14.2) resulting in the late development of unilateral retinoblastoma. Although she only developed unilateral retinoblastoma, her central nervous system was affected at a very early age. How her complex mutation resulted in retinoblastoma and antecedent sPNET remains unknown.

  • 出版日期2013-6

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