Ameliorative effects of Enydra fluctuans flavonoids against acephate toxicity in rat brain

作者：Datta Sanjukta^*; Ghosh Santinath; Dhar Pubali; Ghosh Mahua

来源：Journal of the Indian Chemical Society, 2014, 91(7): 1327-1333.

• Flavonoids
• oxidative stress
• lipid peroxidation
• antioxidant enzymes
• radical scavenging activity

Acephate, an organophosphorus pesticide, induces oxidative stress via free radical generation hampering tissues. Protective role of antioxidants present in Enydra fluctuans was evaluated against its toxicity. Male rats of Charles Foster strain treated orally with acephate (30 mg/kg bwt) and Enydra fluctuans extract (EFE) (20 mg of polyphenolic compounds expressed as gallic acid equivalents/kg bwt) for 14 days demonstrated a significant increase in SOD and non-enzymatic GSH, compared to normal and EFE gavaged groups, and decrease in catalase and GPx levels in brain of acephate treated group. An increased total cholesterol level was also noted. In vitro DPPH and ABTS(+center dot) radical scavenging and reducing activities and lipid peroxidation, tested both in presence and absence of acephate, showed reduced activities in acephate treated tests. The present study gives an insight into the ill-effects of this organophosphate pesticide and the protective role of leafy vegetable polyphenols in minimizing those effects.

• 出版日期2014-7