Antiurease and anti-oxidant activity of Vaccinium macrocarpon fruit

作者：Noreen Shabana; Shaheen Ghazala; Akram Muhammad^*; Rashid Abid; Shah Syed Muhammad Ali

来源：Pakistan Journal of Pharmaceutical Sciences, 2016, 29(4): 1383-1385.

• Vaccinium macrocarpon
• antiurease activity
• anti-oxidant activity

The objective of present study was to evaluate the antiurease and anti-oxidant activity of Vaccinium macrocarpon fruit. The parent extract was ethanolic extract while its sub fractions were prepared in n-hexane, chloroform and n-butanol. The method based on scavenging activity and reduction capability of 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH). N-butanol fraction was the most effective antioxidant with 87.0 +/- 1.15 activity but the activity was less than ascorbic acid i.e. 93.74 +/- 0.12. Highly significant urease inhibition was shown by crude ethanolic extract (71.00 +/- 0.2a) with IC50 (392.66 +/- 2.1) followed by aqueous fraction (68.00 +/- 0.5e) with IC50 (159.83 +/- 2.8). The results of crude ethanolic extract and aqueous extracts were highly significant (p<0.05) than standard Thiourea. Present study showed that Vaccinium macrocarpon exhibits potent antiurease and antioxidant activities.

• 出版日期2016-7