Behaviour of HUVECs adhered on patterned HA on titanium

作者：Liao Yu Zhen^*; Yang Ping; Wang Jin; Huang Nan

来源：Journal of Functional Materials, 2010, 41(10): 1807-1809.

• Cytoskeletal
• Edge definition
• Endothelialization
• High molecular weight
• HUVECs
• Hyaluronic acid
• Hyaluronic acids
• Micro patterning
• Micro-scales
• Micropatterned
• Resistance properties
• SIMPLE method
• Soft-lithography
• Titanium substrates

Micropatterned hyaluronic acid (HA) was fabricated by the method of soft-lithography on the surface of titanium. Endothelial cells (ECs) were confined to a certain place due to the HA of high molecular weight with the resistance property of cell adhesion. Then, the morphology and cytoskeletal conformation of ECs were investigated. The results indicated that micropatterned HA with microscale and with good edge definition were successfully formed on titanium substrates. ECs were confined to a certain place not covered with HA effectively and elongated, the cell's actin was consistent with its morphology. The simple method made cells' morphology changed could be used for both further research of cells' function and endothelialization.

• 出版日期2010
• 单位西南交通大学