A prospective study of erythrocyte polyunsaturated fatty acid, weight gain, and risk of becoming overweight or obese in middle-aged and older women

作者：Wang Lu^*; Manson JoAnn E; Rautiainen Susanne; Gaziano J Michael; Buring Julie E; Tsai Michael Y; Sesso Howard D

来源：European Journal of Nutrition, 2016, 55(2): 687-697.

DOI：10.1007/s00394-015-0889-y

• Fatty acids
• Prospective study
• Women
• Obesity
• Weight gain

omega 3 and omega 6 fatty acids (FA) may have divergent effects on the development of obesity. We examined the association of baseline erythrocyte omega 3 and omega 6 FA composition with body weight change and the risk of becoming overweight or obese in the Women's Health Study (WHS) participants.
We identified 534 women who had baseline erythrocyte FA measured and a baseline body mass index (BMI) of 18.5-< 25 kg/m(2). Body weight was updated at a total of six time points during follow-up.
Weight gain during a mean of 10.4-year follow-up increased with increasing quartiles of baseline erythrocyte cis omega 6 FA, omega 6/omega 3 ratio, and trans FA while decreased with increasing cis omega 3 FA. After multivariable adjustment including total energy intake and physical activity, the weight gain (kg) in the highest versus the lowest quartile was 3.08 versus 2.32 for erythrocyte cis omega 6 FA (p (trend) 0.04), 2.07 versus 2.92 for cis omega 3 FA (p (trend) 0.08), 2.93 versus 2.05 for omega 6/omega 3 ratio (p (trend) 0.046), and 3.03 versus 2.27 for trans FA (p (trend) 0.06). Among individual FA, the associations were significant for 18:2 omega 6, 18:3 omega 6, and trans 18:1 and marginally significant for 20:3 omega 6 and trans 18:2. The risk of becoming overweight or obese (defined as BMI a parts per thousand yen25 kg/m(2) at any follow-up time point) increased across increasing omega 6/omega 3 ratio (multivariable model p (trend) 0.04).
In this prospective study, we found suggestive evidence that erythrocyte cis omega 6 FA may be positively associated, and cis omega 3 FA inversely associated with weight gain in initially normal-weight women.

• 出版日期2016-3