Design, Synthesis, and Photochemical Validation of Peptide Linchpins Containing the S,S-Tetrazine Phototrigger

作者：Abdo Mohannad; Brown Stephen P; Courter Joel R; Tucker Matthew J; Hochstrasser Robin M^*; Smith Amos B III

来源：Organic Letters, 2012, 14(13): 3518-3521.

DOI：10.1021/ol301490h

The design, solid-phase synthesis, and photochemical validation of diverse peptide linchpins, containing the S,S-tetrazine phototrigger, have been achieved. Steady state irradiation or femtosecond laser pulses confirm their rapid photofragmentation. Attachment of peptides to the C- and N-termini will provide access to diverse constrained peptide constructs that hold the promise of providing information about early peptide/protein conformational dynamics upon photochemical release.

• 出版日期2012-7-6