Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics

作者：Pulley Jill M^*; Shirey Rice Jana K; Lavieri Robert R; Jerome Rebecca N; Zaleski Nicole M; Aronoff David M; Bastarache Lisa; Niu Xinnan; Holroyd Kenneth J; Roden Dan M; Skaar Eric P; Niswender Colleen M; Marnett Lawrence J; Lindsley Craig W; Ekstrom Leeland B; Bentley Alan R; Bernard Gordon R; Hong Charles C; Denny Joshua C

来源：Assay and Drug Development Technologies, 2017, 15(3): 113-119.

DOI：10.1089/adt.2016.772

• PheWAS
• BioVU
• genetics
• translational research
• repurposing

The potential impact of using human genetic data linked to longitudinal electronic medical records on drug development is extraordinary; however, the practical application of these data necessitates some organizational innovations. Vanderbilt has created resources such as an easily queried database of >2.6 million de-identified electronic health records linked to BioVU, which is a DNA biobank with more than 230,000 unique samples. To ensure these data are used to maximally benefit and accelerate both de novo drug discovery and drug repurposing efforts, we created the Accelerating Drug Development and Repurposing Incubator, a multidisciplinary think tank of experts in various therapeutic areas within both basic and clinical science as well as experts in legal, business, and other operational domains. The Incubator supports a diverse pipeline of drug indication finding projects, leveraging the natural experiment of human genetics.

• 出版日期2017-4