Adeno-Associated Virus Type 2 Rep68 Can Bind to Consensus Rep-Binding Sites on the Herpes Simplex Virus 1 Genome

作者：Seyffert Michael; Glauser Daniel L; Tobler Kurt; Georgiev Oleg; Vogel Rebecca; Vogt Bernd; Agundez Leticia; Linden Michael; Buening Hildegard; Ackermann Mathias; Fraefel Cornel^*

来源：Journal of Virology, 2015, 89(21): 11150-11158.

DOI：10.1128/JVI.01370-15

Adeno-associated virus type 2 is known to inhibit replication of herpes simplex virus 1 (HSV-1). This activity has been linked to the helicase- and DNA-binding domains of the Rep68/Rep78 proteins. Here, we show that Rep68 can bind to consensus Rep-binding sites on the HSV-1 genome and that the Rep helicase activity can inhibit replication of any DNA if binding is facilitated. Therefore, we hypothesize that inhibition of HSV-1 replication involves direct binding of Rep68/Rep78 to the HSV-1 genome.

• 出版日期2015-11