A Novel and Convenient Protocol for Synthesis of Pyridazines

作者：Attanasi Orazio A; Favi Gianfranco^*; Filippone Paolino; Perrulli Francesca R; Santeusanio Stefania

来源：Organic Letters, 2009, 11(2): 309-312.

DOI：10.1021/ol802432z

A new flexible strategy for the synthesis of diversely functionalized pyridazines from 4-chloro-1,2-diaza-1,3-butadienes and active methylene compounds is reported. The high chemoselectivity of this approach offers access to structural precursors of GABA-A antagonist analogues.

• 出版日期2009-1-15