Diagnostic feasibility and safety of CT-guided core biopsy for lung nodules less than or equal to 8 mm: A single-institution experience

作者：Chang Ying-Yueh; Chen Chun-Ku^*; Yeh Yi-Chen; Wu Mei-Han

来源：European Radiology, 2018, 28(2): 796-806.

DOI：10.1007/s00330-017-5027-1

• Image-guided biopsy
• Computed tomography
• Lung neoplasms
• Pulmonary nodule
• Diagnostic accuracy

This retrospective study evaluated the diagnostic yield and safety of CT-guided core biopsy of pulmonary nodules 8 mm.
We determined the diagnostic yield and safety profile of CT-guided lung biopsies for 125 pulmonary nodules 8 mm. Pathological diagnoses were made by a combination of histopathological examination and imprint cytology. Results were compared with biopsy results for 134 pulmonary nodules > 8 and 10 mm.
Final diagnoses were established in 94 nodules 8 mm. The sensitivity, specificity and diagnostic accuracy of CT-guided core biopsy for nodules 8 mm were 87.1 % (61/70 nodules), 100 % (24/24) and 90.4 % (85/94), respectively. Diagnostic failure rates were comparable for nodules 8 mm and nodules > 8 mm and 10 mm (9/94, 9.6 % and 7/111, 6.3 %, respectively, P=0.385). The rate of tube thoracostomy for nodules 8 mm was comparable to that for nodules > 8 and 10 mm (1.6 % vs. 0.7 %, P=0.611). Nodules 6 mm had a higher non-diagnostic result rate of 15.4 % (6/39) than did nodules > 8 and 10 mm (3.7 %, 5/134, P=0.017).
CT-guided pulmonary biopsy is feasible for lung nodules 8 mm, especially those > 6 mm, and has an acceptable diagnostic yield and safety profile.

• 出版日期2018-2