FeCl3-SiO2 as a reusable heterogeneous catalyst for the synthesis of 5-substituted 1H-tetrazoles via [2 3] cycloaddition of nitriles and sodium azide

作者：Nasrollahzadeh Mahmoud^*; Bayat Yadollah; Habibi Davood; Moshaee Saeed

来源：Tetrahedron Letters, 2009, 50(31): 4435-4438.

DOI：10.1016/j.tetlet.2009.05.048

• 5-Substituted 1H-tetrazole
• [3 2] Cycloaddition
• Nitrile
• FeCl3-SiO2
• Heterogeneous catalyst

An efficient method for the preparation of 5-substituted 1H-tetrazole derivatives is reported using FeCl3-SiO2 as an effective heterogeneous catalyst. This method has the advantages of high yields, simple methodology, and easy work-up. The catalyst can be recovered by simple filtration and reused delivering good yields.

• 出版日期2009-8-5