A flow system for the on-line quantitative measurement of the retention of dosage forms on biological surfaces using spectroscopy and image analysis

作者：Cave Richard A; Cook Joseph P; Connon Che J; Khutoryanskiy Vitaliy V^*

来源：International Journal of Pharmaceutics, 2012, 428(1-2): 96-102.

DOI：10.1016/j.ijpharm.2012.02.047

• Bioadhesion
• Mucoadhesion
• Image analysis
• UV/vis spectroscopy
• In vitro models
• Residence time
• Drug delivery

Measuring the retention, or residence time, of dosage forms to biological tissue is commonly a qualitative measurement, where no real values to describe the retention can be recorded. The result of this is an assessment that is dependent upon a user%26apos;s interpretation of visual observation. This research paper outlines the development of a methodology to quantitatively measure, both by image analysis and by spectrophotometric techniques, the retention of material to biological tissues, using the retention of polymer solutions to ocular tissue as an example. Both methods have been shown to be repeatable, with the spectrophotometric measurement generating data reliably and quickly for further analysis.

• 出版日期2012-5-30