Association between caffeine intake and age at onset in Huntington%26apos;s disease

作者：Simonin Clemence^*; Duru Cecile; Salleron Julia; Hincker Pascale; Charles Perrine; Delval Arnaud; Youssov Katia; Burnouf Sylvie; Azulay Jean Philippe; Verny Christophe; Scherer Clarisse; Tranchant Christine; Goizet Cyril; Debruxelles Sabrina; Defebvre Luc; Sablonniere Bernard; Romon Rousseaux Monique; Buee Luc; Destee Alain; Godefroy Olivier; Duerr Alexandra; Landwehrmeyer Bernhard; Bachoud Levi Anne Catherine; Richard Florence; Blum David; Krystkowiak Pierre

来源：Neurobiology of Disease, 2013, 58: 179-182.

DOI：10.1016/j.nbd.2013.05.013

• Huntington%26apos
• s disease
• Caffeine
• Adenosine receptors

Habitual consumption of caffeine, a non-selective adenosine receptor (AR) antagonist, has been suggested to be beneficial in Parkinson%26apos;s and Alzheimer%26apos;s diseases. Experimental evidence support that ARs play a role in Huntington%26apos;s disease (HD) raising the hypothesis that caffeine may be a life-style modifier in HD. To determine a possible relationship between caffeine consumption and age at onset (AAO) in HD, we retrospectively assessed caffeine consumption in 80 HD patients using a dietary survey and determined relationship with AAO. Following adjustment for gender, smoking status and CAG repeat length, caffeine consumption greater than 190 mg/day was significantly associated with an earlier AAO. These data support an association between habitual caffeine intake and AAO in HD patients, but further studies are warranted to understand the link between these variables.

• 出版日期2013-10