Association between serum levels of vascular endothelial growth factor, macrophage inhibitory cytokine and markers of oxidative stress, with the metabolic syndrome and its components in obese individuals

作者：Shariat Atefeh; Farhangi Mandieh Abbasalizad^*; Zeinahan Reihaneh

来源：Nutrition Clinique et Metabolisme, 2018, 32(2): 95-101.

DOI：10.1016/j.nupar.2018.02.003

• Metabolic Syndrome
• VEGF
• MIC-1
• Oxidative stress

Aim. - Metabolic syndrome (MetS) is a clinical disorder with widespread prevalence. In the current study, we aimed to investigate the serum values of macrophage inhibitory cytokine (MIC)-1, vascular endothelial growth factor (VEGF) and markers of oxidative stress among patients with metabolic syndrome.
Material and methods. - Twenty obese patients with MetS and 20 obese apparently healthy controls were participated in the current case-control study. The participants' body mass index (BMI), waist circumference (WC), systolic and diastolic blood pressure (SBP and DBP) were measured. Serum levels of total cholesterol (TC), triglyceride (TG), low and high density lipoprotein cholesterol (LDL-c and HDL-c), vascular endothelial growth factor (VEGF), MIC-1 (macrophage inhibitory cytokine 1), superoxide dismutase (SOD) and glutathione peroxidase (GPX) were also determined by commercial ELIZA kits.
Results. - Participants in MetS group had higher levels of WC, DBP and higher serum concentrations of TG and TC compared with control group (P < 0.05). Serum VEGF and MIC-1 levels were significantly higher in patients with MetS compared with control subjects (P < 0.05). There was a significant and positive association between serum levels of VEGF and LDL (P = 0.027; beta = 0.453) in all of the study participants. Moreover, an inverse association between serum GPX with DBP and between SOD with WC were also seen (P < 0.05).
Conclusion. - The higher serum values of MIC-1 and VEGF in patients with MetS and the negative association of VEGF with serum LDL concentrations opened a new window about the possible pathologic role of these factors in the etiology or pathophysiology of MetS. Further studies are warranted for solidification of achieved results.

• 出版日期2018-5