Antibody B cell responses in HIV-1 infection

作者：Mouquet Hugo^*

来源：Trends in Immunology, 2014, 35(11): 549-561.

DOI：10.1016/j.it.2014.08.007

• HIV-1
• antibodies
• B cells
• adaptive immunity
• viruses

In rare cases, B cells can supply HIV-1-infected individuals with unconventional antibodies equipped to neutralize the wide diversity of viral variants. Innovations in single-cell cloning, high-throughput sequencing, and structural biology methods have enabled the capture and thorough characterization of these exceptionally potent broadly neutralizing antibodies (bNAbs). Here, I review the recent findings in humoral responses to HIV-1, focusing on the interplay between naturally occurring bNAbs and the virus both at systemic and mucosa! levels. In this context, I discuss how an improved understanding of bNAb generation may provide invaluable insight into the fundamental mechanisms governing adaptive B cell responses to viruses, and how this knowledge is currently contributing to the development of vaccine and therapeutic strategies against HIV-1.

• 出版日期2014-11