Anti-Tissue Antibodies Are Related to Lung Function in Chronic Obstructive Pulmonary Disease

作者：Nunez Belen; Sauleda Jaume^*; Maria Anto Josep; Rosa Julia Maria; Orozco Mauricio; Monso Eduard; Noguera Aina; Gomez Federico P; Garcia Aymerich Judith; Agusti Alvar

来源：American Journal of Respiratory and Critical Care Medicine, 2011, 183(8): 1025-1031.

DOI：10.1164/rccm.201001-0029OC

• autoimmunity
• bronchitis
• emphysema
• immune system
• tobacco

Rationale: Chronic obstructive pulmonary disease (COPD) is a multicomponent disease. Autoimmunity can contribute to the pathogenesis of COPD.
Objectives: This study investigates the prevalence of circulating antinuclear antibodies (ANA) and anti-tissue (AT) antibodies, two common markers of autoimmunity, in COPD and their relationship with several components of the disease.
Methods: We determined lung function, the serum titers of ANA and AT by immunofluorescence, and the serum levels of C-reactive protein (CRP) by high sensitivity nephelometry in 328 patients with clinically stable COPD and in 67 healthy controls recruited in the PAC-COPD study. Multiple linear and logistic regression analysis was used to analyze results.
Measurements and Main Results: The prevalence of abnormal ANA and AT titers was 34% and 26% in patients and 3% and 6% in controls, respectively. Levels of AT greater than or equal to 1: 320 were seen in 21% of patients with COPD and were independently associated with the severity of airflow limitation and gas transfer impairment (P, 0.05). Neither ANA or AT titers was related to body mass index, current smoking status, use of inhaled steroids, the Charlson index, or serum C-reactive protein values.
Conclusions: Between a quarter and a third of patients with clinically stable COPD present abnormal titers of circulating ANA and AT. The observed relationship between AT and lung function supports a role for autoimmunity in the pathogenesis of COPD.

• 出版日期2011-4-15
• 单位河北医科大学